Cutaneous Necrosis Associated with Protein S Deficiency
نویسندگان
چکیده
منابع مشابه
Type I protein S deficiency and skin necrosis.
A kindred with Type I protein S deficiency is described in which the index case developed skin necrosis during induction of oral anticoagulant therapy for deep venous thrombosis. Two other family members with protein S deficiency have been detected, and demonstrate the clinical variability of this condition.
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Recent studies have demonstrated that protein C deficiency is associated with recurrent familial thrombosis. In plasma, activated protein C functions as an anticoagulant. This anticoagulant response requires a vitamin K-dependent plasma protein cofactor, referred to as protein S. Since the anticoagulant activity of activated protein C is dependent on protein S, we hypothesized that patients lac...
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The answers are a definite YES to (i, ii and iii) and a very clear NO to (iv). Regarding (v), for decades our obstetrician colleagues have been advising, that on which days and how frequently coitus is to be done, in the management of anovulatory infertility, with drugs like clomiphene. Moreover some sort of mental and physical relaxation/drugs before the act are also prescribed, with an advice...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1990
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689008301016